Ig kappa light chain variable region Heavy, Human
Rif. 3D-CRB1301388
| 25nMol | 270,00 € |
Informazioni sul prodotto
- AIQLTQSPSSLSASVGD-[U-13C6,15N4-Arg]-acidH-Ala-Ile-Gln-Leu-Thr-Gln-Ser-Pro-Ser-Ser-Leu-Ser-Ala-Ser-Val-Gly-Asp-[U-13C6,15N4-Arg]-OH
Peptide derived from the variable region on the heavy chain of immunoglobulin (Ig) which is part of the fragment antigen binding (Fab) fragment of antibodies. Ig or antibodies are made up of two heavy and two light chains both of which have a constant region and a variable region. The variable region, the antigen binding site, is composed of three complementarity determining regions (CDRs) from the variable heavy chain and three CDRs from the variable light chains. The amino acid sequences of the variable region differ between each antibody allowing Ig to bind to specific antigens.The variable regions are encoded by a variety of V, D and J gene segments. During somatic recombination different combinations from the V, D and J varieties can be joined together. Consequently this gives rise to a diverse variable region.The light chain can be either of the two types, a lambda or kappa, and the type of light chain does not affect the function of the antibody. The arginine residue is isotopically labelled at position 18 with carbon-13(6) and nitrogen-15(4).
Proprietà chimiche
Richiesta tecnica su: 3D-CRB1301388 Ig kappa light chain variable region Heavy, Human
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