Anti-ERK1/2 antibody - 1mg/mL
Rif. 3D-CRB2005025
| 20µg | 268,00 € | ||
| 100µg | 483,00 € |
Informazioni sul prodotto
Extracellular signal-regulated kinase 1/2 (ERK1/2) is a mitogen-activated protein kinase (MAPK) family protein and part of the Ras-Raf-MEK-ERK signalling pathway which plays a key role in controlling cell proliferation, differentiation and cell survival. ERK1/2 acts downstream of activated growth factor receptors, RAF protein kinases and mitogen-activated protein kinase kinases 1 and 2 (MEK1/2). MEK1 and MEK2 activate ERK1/2 by phosphorylation and once activated ERK1/2 enters the nucleus and phosphorylates transcription factors to induce changes in gene expression. In addition to this active ERK1/2 also translocates to other organelles including the endoplasmic reticulum, endosomes, golgi and mitochondria where it influences cell physiology. Overall ERK1/2 phosphorylates more than 200 different substrates including other protein kinases, transcription factors, RNA-binding proteins, regulators of mRNA translation and regulators of cell death. ERK1/2 pathway is strongly implicated in cancer where its hyperactivation underpins the growth and maintenance of many tumour types.
Data: Western blot analysis of whole cell extract of Mouse embryonic Fibroblasts (MEFs).
Proprietà chimiche
Richiesta tecnica su: 3D-CRB2005025 Anti-ERK1/2 antibody - 1mg/mL
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