Anti-Sgo1 antibody - 1mg/mL
Rif. 3D-CRB2005308
| 20µg | 268,00 € | ||
| 100µg | 483,00 € |
Informazioni sul prodotto
Timely chromosome segregation during mitosis and meiosis is orchestrated by separase activity cleaving the multi-subunit cohesin complex from the centromere. Sister chromosomes remain attached at the centromere till after meiosis I anaphase due to shugoshins protecting cohesin from separase activity. Recent work shows shugoshin's role is to interact with PP2A and maintaining cohesin in a dephosphorylated state thus protecting the centromeric RecB protein from separase activity.
In mammals, there are 2 known sugoshins paralogues, Sgo1 and Sgo2. Sgo1 appears to play the primary role in cohesin protection during mitosis when most cohesin complex dissociates from the chromosome arms. Whereas Sgo2 aids centromeric cohesion during meiosis. Reduced levels of Sgo1 have been associated with colorectal cancers due to the increased chromosomal instability leading to tumourigenesis. Defective Sgo1 has also been linked to aneuploidy. This KLH conjugated Sgo1 antibody is the ideal research tool to investigate the functions of shugoshins as there is still much to uncover.
Proprietà chimiche
Richiesta tecnica su: 3D-CRB2005308 Anti-Sgo1 antibody - 1mg/mL
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