GENZ-644282
CAS: 529488-28-6
Rif. 3D-EWA48828
| 10mg | 477,00 € | ||
| 25mg | 681,00 € | ||
| 50mg | 1.038,00 € | ||
| 100mg | 1.528,00 € | ||
| 250mg | 2.199,00 € |
Informazioni sul prodotto
GENZ-644282 is a drug transporter that is structurally similar to the natural compound quinoline. It has been shown to have significant cytotoxicity in vitro against cancer cells, and it has been shown to be effective in vivo against colorectal adenocarcinoma. This compound can act as a prodrug for other drugs, such as doxorubicin and paclitaxel. The mechanism of action of GENZ-644282 is not yet fully understood, but it may be due to its ability to inhibit the function of the p-glycoprotein protein in tumor xenografts.
GENZ-644282 also inhibits the function of ABCG2, an ATP binding cassette transporter protein that transports lipophilic molecules from the cell membrane into the cell interior. This inhibition leads to accumulation of lipophilic substances in the extracellular space and increased permeability of tumor cells, which causes cell death by apoptosis or necrosis.
Proprietà chimiche
Richiesta tecnica su: 3D-EWA48828 GENZ-644282
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