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4-Amino-1-tert-butyl-3-(1'-naphthyl)pyrazolo[3,4-d]pyrimidine
CAS: 221243-82-9
Rif. 3D-FA10426
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Informazioni sul prodotto
- 1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- 1-Na-Pp 1
- 1-Na-Pp1
- 1-Naphthyl PP 1
- 1-tert-Butyl-3-(1-naphthyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- 1-tert-Butyl-3-naphthalen-1-ylpyrazolo[3,4-d]pyrimidin-4-amine
- 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-
- PP1 analog
4-Amino-1-tert-butyl-3-(1'-naphthyl)pyrazolo[3,4-d]pyrimidine is a JAK2 inhibitor that has been shown to have anti-proliferative effects on prostate cancer cells. It is an analog of the natural compound 1,4-diaminobutane. 4-Amino-1-tert-butyl-3-(1'-naphthyl)pyrazolo[3,4-d]pyrimidine binds to the ATP site of protein kinase JAK2 and prevents phosphorylation of tyrosine residue 1085 in the activation loop. This inhibition leads to decreased activity of signal pathways such as the MAPK pathway and reduced expression of mesenchymal markers. The normal production of fatty acids and lysine is also inhibited by this drug. 4ATBP also causes apoptosis by inhibiting receptor activity and increasing
Proprietà chimiche
Richiesta tecnica su: 3D-FA10426 4-Amino-1-tert-butyl-3-(1'-naphthyl)pyrazolo[3,4-d]pyrimidine
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