Dabrafenib

CAS: 1195765-45-7

Rif. 3D-FA65034

Informazioni sul prodotto

• Nome: Dabrafenib
• Sinonimi: N-(3-(5-(2-Aminopyrimidine-4-yl)-2-tert-butylthiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamideGSK2118436A, Benzenesulfonamide, N-[3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-, Dabarefenib, Debrafenib free base, Gsk 2118436, Gsk 436, N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide, N-[3-[5-(2-Aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide, Tafinlar, Tafmlar
• CAS: 1195765-45-7

Descrizione

Inhibitor of mutant B-rafV600E protein that results in decreased proliferation of cancer cells with this mutation. Treatment of metastatic melanoma in patients harboring the V600E mutation, had improved disease outcome. This antitumor activity is enhanced when combined with MEK inhibitor trametinib.

• Marchio: Biosynth

Proprietà chimiche

• Peso molecolare: 519.56 g/mol
• Formula: C₂₃H₂₀F₃N₅O₂S₂
• Purezza: Min. 95%
• Colore/Forma: Powder
• InChI: InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29)
• InChI key: InChIKey=BFSMGDJOXZAERB-UHFFFAOYSA-N
• SMILES: CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(N)n2)s1