Modulatori enzimatici
Sottocategorie di "Modulatori enzimatici"
Trovati 649 prodotti per "Modulatori enzimatici".
SB 239063
CAS:Inhibits p38 MAP kinase; anti-inflammatory; neuroprotectiveFormula:C20H21FN4O2Purezza:Min. 95%Colore e forma:PowderPeso molecolare:368.4 g/molSivelestat
CAS:Inhibitor of human neutrophil elastase
Formula:C20H22N2O7SPurezza:Min. 95%Peso molecolare:434.46 g/molRepSox
CAS:Selective inhibitor of the transforming growth factor beta receptor TGFβ1. RepSox can replace Sox, a transcriptional factor required for cell self-renewal, in reprogramming of adult cells to induced pluripotent stem cells (iPSCs). In the cloned interspecies embryos, RepSox induced expression of pluripotency regulatory genes Oct4 and Nanog, improved viability and developmental potential of embryos in the pre-implantation stage.
Formula:C17H13N5Purezza:Min. 95%Colore e forma:PowderPeso molecolare:287.32 g/molMotesanib
CAS:Inhibitor of VEGFR, PDGR, c-Kit and Ret; inhibitor of angiogenesisFormula:C22H23N5OPurezza:Min. 95%Peso molecolare:373.45 g/molLY 411575
CAS:Potent inhibitor of γ-secretase. LY 411575 inhibited production of amyloid β (Aβ) peptides with IC50 of 0.078 nM in vitro as well as decreased levels of Aβ40 and Aβ42 amyloids in brain of a mouse model for Alzheimer’s disease. In vitro studies confirmed that LY 411575 inhibited cleavage of Notch receptor at S3 site with IC50 of 0.39 nM, which blocked Notch activation and downstream signalling, leading to apoptosis in primary and immortalized Kaposi's sarcoma cells.Formula:C26H23F2N3O4Purezza:Min. 95%Colore e forma:SolidPeso molecolare:479.48 g/molAfatinib - Bio-X ™
CAS:Afatinib is a small molecule that inhibits the activity of cellular kinases that are involved in the progression of cancer. It is an Irreversible inhibitor of three members of the ErbB family. This molecule binds covalently to cysteine 797 residue in HER2 and blocks downstream cellular signalling which inhibits cellular growth and promotes apoptosis. It has been researched for the treatment of non-small cell lung cancer (NSCLC), breast cancer, pancreatic cancer and colorectal cancer.Formula:C24H25ClFN5O3Purezza:Min. 95%Colore e forma:PowderPeso molecolare:485.94 g/molSemagacestat
CAS:γ-secretase inhibitor; inhibits notch signaling
Formula:C19H27O4N3Purezza:Min. 95%Peso molecolare:361.44 g/molToceranib phosphate - Bio-X ™
CAS:Prodotto controllatoToceranib phosphate is a receptor tyrosine kinase inhibitor. Toceranib phosphate has been shown to be effective in the treatment of skin cancer and other types of cancer, including lung cancer and breast cancer. It is approved in the US as a treatment for canine mastocytoma (mast cell tumours).Formula:C22H25FN4O2·H3O4PPurezza:Min. 95%Colore e forma:PowderPeso molecolare:494.45 g/molCapmatinib
CAS:Selective c-Met kinase inhibitor
Formula:C23H17FN6OPurezza:Min. 95 Area-%Colore e forma:Slightly Yellow PowderPeso molecolare:412.42 g/mol(Z)-Mycophenolic acid
CAS:(Z)-Mycophenolic acid is an immunosuppressive agent derived from the fermentation of fungi, primarily from the Penicillium species. It functions by inhibiting inosine monophosphate dehydrogenase (IMPDH), an enzyme crucial for de novo purine synthesis. This selective blockade of IMPDH specifically affects lymphocyte proliferation due to their heavy reliance on this pathway for DNA synthesis, thereby exerting its immunosuppressive effects.Formula:C17H20O6Purezza:Min. 98 Area-%Colore e forma:PowderPeso molecolare:320.34 g/molUNC 4203
CAS:Potent and specific inhibitor of the tyrosine protein kinase Mer precursor (MERTK) with 38-fold selectivity over the FMS-like protein kinase FLT3. UNC 4203 inhibits MERTK with an IC50 value of 2.4 nM and shows favourable pharmacokinetic properties. In vivo experiments in mice showed that UNC 4203 dramatically decreased the phosphorylation of MERTK in bone marrow leukemia cells.Formula:C30H44N6OPurezza:Min. 95%Colore e forma:Yellow PowderPeso molecolare:504.71 g/molGDC 0941
CAS:Pan-class I phosphatidylinositide 3-kinase (PI3K) inhibitor (IC50 = 3, 33, 3 and 75 nM at catalytic subunits p110α, p110β, p110δ and p110γ respectively). Inhibits proliferation in several cancer cell lines, such as glioblastoma, breast and prostate cancer cells. Has synergistic anti-cancer effect in combination with MEK/ERK kinase inhibitor GDC-0973 (cobimetinib).
Formula:C23H27N7O3S2Purezza:Min. 95%Colore e forma:White PowderPeso molecolare:513.64 g/molNilotinib HCl monohydrate - Bio-X ™
CAS:Nilotinib is a kinase inhibitor that is used for the treatment of Chronic Myeloid Leukemia (CML). This drug is also used for the treatment of CML that is resistant to imatinib. Nilotinib inhibits the tyrosine kinase activity of the BCR-ABL protein. It also inhibits PDGFR and c-kit.
Formula:C28H22F3N7O•HCl•H2OPurezza:Min. 95%Colore e forma:PowderPeso molecolare:583.99 g/mol(-)-Huperzine A
CAS:Acetylcholinesterase inhibitor; therapy for Alzheimer's diseaseFormula:C15H18N2OPurezza:(%) Min. 98%Colore e forma:PowderPeso molecolare:242.32 g/molCYT 387
CAS:Inhibits JAK1 and JAK2 kinasesFormula:C23H22N6O2Purezza:Min. 95%Colore e forma:PowderPeso molecolare:414.46 g/molGC376 sodium
CAS:GC 376 is an inhibitor of the main protease Mpro (3CLpro) in coronaviruses as well as picornaviruses. This broad-spectrum antiviral compound has been used as investigational veterinary drug for treatment of feline infectious peritonitis virus (FIPV) infections. Recent studies also showed that GC 376 inhibits the main protease Mpro (3CLpro) from SARS-CoV-2 with IC50 of 0.03 μM and EC50 of 3.37 μM.
Formula:C21H30N3NaO8SPurezza:Min. 95 Area-%Colore e forma:White PowderPeso molecolare:507.53 g/molPF 06409577
CAS:Potent agonist of a1β1γ1 5′-adenosine monophosphate-activated protein kinase (AMPK). It binds to the allosteric drug and metabolite (ADaM) site at the α- and β- subunit interface of AMPK. It has potential for the treatment of diabetic nephropathy. PF 06409577 reduces infections caused by flaviviruses, mediated by changes in the metabolism of lipids in host cells.
Formula:C19H16ClNO3Purezza:Min. 95%Colore e forma:White/Off-White SolidPeso molecolare:341.79 g/molRoflumilast - Bio-X ™
CAS:Roflumilast is a selective phosphodiesterase-4 inhibitor that is used for the treatment of exacerbations in patients with chronic obstructive pulmonary disease (COPD). It is also used to treat plaque psoriasis. This drug has anti-inflammatory and immunomodulatory effects as it aids in increasing levels of cAMP.
Formula:C17H14Cl2F2N2O3Purezza:Min. 95%Colore e forma:PowderPeso molecolare:403.21 g/molNabumetone - Bio-X ™
CAS:Nabumetone is a non-steroidal anti-inflammatory drug that is used in the treatment of osteoarthritis and rheumatoid arthritis. This drug is also a cyclooxygenase inhibitor and works by inhibiting this enzyme so that pain and inflammation is reduced.Formula:C15H16O2Purezza:Min. 95%Colore e forma:PowderPeso molecolare:228.29 g/molMethotrexate
CAS:Methotrexate is a chemotherapeutic and immunosuppressive medication, which is a synthetic analog of folic acid. Its source is through chemical synthesis, mimicking the structure of dihydrofolate in order to exert its effects. Methotrexate acts primarily by inhibiting the enzyme dihydrofolate reductase (DHFR), leading to a decrease in tetrahydrofolate production. This disruption in folate metabolism results in the inhibition of DNA, RNA, and protein synthesis, which affects rapidly dividing cells.Methotrexate is employed broadly in clinical oncology as an antineoplastic agent, particularly in the treatment of leukemias, lymphomas, breast cancer, and osteosarcoma. Additionally, it serves as a cornerstone for managing autoimmune diseases such as rheumatoid arthritis and psoriasis, where it helps modulate the aberrant immune response. The dual role of Methotrexate in oncology and immunosuppression underscores its versatility and critical importance in therapeutic regimens. However, its use demands careful monitoring due to potential adverse effects on non-cancerous cells and organ systems, necessitating precise dosage management and patient evaluation.Formula:C20H22N8O5Colore e forma:Yellow PowderPeso molecolare:454.44 g/mol
