2-(Bis(2-chloroethyl)amino)-4-hydroxy-1,3,2-oxazaphosphinane 2-oxide
CAS: 40277-05-2
Rif. 3D-FB175219
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Informazioni sul prodotto
- 2-[Bis(2-chloroethyl)amino]-4-hydroxy-1,3,2λ5-oxazaphosphinan-2-one
- 2-[Bis(2-chloroethyl)amino]tetrahydro-4-hydroxy-2H-1,3,2-oxazaphosphorine 2-oxide
- 2H-1,3,2-Oxazaphosphorine, 2-(bis(2-chloroethyl)amino)-4-hydroxytetrahydro-, 2-oxide
- 2H-1,3,2-oxazaphosphorin-4-ol, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide
- 4-Hydroxycyclophosphamide
- Asta 6635
- NSC 196562
This compound is a phosphoramidate analog of cyclophosphamide. It has been shown to have an effect on the glomerular filtration rate and to inhibit DNA, RNA, and protein synthesis in human cells. The compound binds to the dinucleotide phosphate (NDP) site of the enzyme polymerase chain reaction (PCR) with high affinity, and inhibits DNA synthesis by competing with ATP. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. The kinetics of this drug have been studied using a concentration-time curve on human serum samples. The matrix effect can be avoided by preparing samples for analysis in a liquid phase instead of a solid phase. The analytical method for this drug has been developed in heart tissue preparations from rats treated with this drug at
Proprietà chimiche
Richiesta tecnica su: 3D-FB175219 2-(Bis(2-chloroethyl)amino)-4-hydroxy-1,3,2-oxazaphosphinane 2-oxide
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