Cyclopropanecarboxamidoximemonohydrochloride
CAS: 22926-85-8
Rif. 3D-FC149444
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Informazioni sul prodotto
- N'-hydroxycyclopropanecarboximidamide hydrochloride
Cyclopropanecarboxamidoxime hydrochloride (CPCA) is a diazine compound that is used as an anti-tuberculosis drug. It is the most potent of the diazine compounds for the treatment of tuberculosis. CPCA inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. CPCA also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.
Proprietà chimiche
Richiesta tecnica su: 3D-FC149444 Cyclopropanecarboxamidoximemonohydrochloride
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