1-(2-Chloro-4-(4-chlorophenyl)butyl)-1H-imidazole

CAS: 67085-12-5

Rif. 3D-FC150297

Informazioni sul prodotto

• Nome: 1-(2-Chloro-4-(4-chlorophenyl)butyl)-1H-imidazole
• Sinonimi: 1H-imidazole, 1-[2-chloro-4-(4-chlorophenyl)butyl]-

Descrizione

1-(2-Chloro-4-(4-chlorophenyl)butyl)-1H-imidazole (1-CHLBI) is a synthetic compound that has been shown to inhibit the replication of retroviruses. It binds to the hydroxyl group on the nitrogen atom of furyl, which is part of a nucleotide in the viral dna, and prevents its incorporation into the growing chain. This inhibits rna synthesis and protein synthesis, leading to cell death and inhibition of virus production. 1-CHLBI also has antiviral activity against HIV infection. The trifluoromethyl group at position 1 prevents the metabolism by cytochrome P450 enzymes, while the nitro group at position 2 acts as an electron donor in an oxidation reaction with glutathione reductase or cytochrome P450 enzymes. 1-CHLBI also has an amide bond that can be hydrolyzed by esterases or glucuron

• Marchio: Biosynth

Proprietà chimiche

• Peso molecolare: 269.17 g/mol
• Formula: C₁₃H₁₄Cl₂N₂
• Purezza: Min. 95%
• InChI: InChI=1S/C13H14Cl2N2/c14-12-4-1-11(2-5-12)3-6-13(15)9-17-8-7-16-10-17/h1-2,4-5,7-8,10,13H,3,6,9H2
• InChI key: InChIKey=PJMMKIMXEKRAAT-UHFFFAOYSA-N
• SMILES: Clc1ccc(CCC(Cl)Cn2ccnc2)cc1