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1-(3,5-Dichlorophenyl)-1H-pyrrole-2,5-dione
CAS: 24096-52-4
Rif. 3D-FD137280
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Informazioni sul prodotto
- 1H-pyrrole-2,5-dione
- 1-(3,5-dichlorophenyl)-
- N-(3,5-Dichlorophenyl)maleimide
- 3,5-Ndpm
- 1H-Pyrrole-2,5-dione, 1-(3,5-dichlorophenyl)-
- 1-(3,5-dichlorophenyl)-1H-pyrrole-2,5-dione
3,5-Dichloro-1-(2,5-dioxopyrrolidin-1-yl)benzene (DLP) is a ligand that has been shown to bind to cancer cells at micromolar concentrations. DLPs also have diagnostic imaging properties and can be used in the diagnosis of cancer. The affinities of DLP for different cancers have been determined by analyzing the unpurified compounds in their low micromolar range. When DLP binds to cancer cells it alters their permeability, which causes the cell to take up more chloride ions from its environment. This results in an increase in the number of chloride ions inside the cell and a decrease in the number outside. This difference creates a voltage gradient across the cell membrane that is detected by laser confocal microscopy as a change in fluorescence intensity. DLP has also been shown to inhibit lung cancer tumor growth at micromolar concentrations.
Proprietà chimiche
Richiesta tecnica su: 3D-FD137280 1-(3,5-Dichlorophenyl)-1H-pyrrole-2,5-dione
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