3-Demethyl thiocolchicine
CAS: 87424-25-7
Rif. 3D-FD21016
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Informazioni sul prodotto
- N-[(7S)-3-Hydroxy-1,2-Dimethoxy-10-(Methylthio)-9-Oxo-6,7-Dihydro-5H-Benzo[D]Heptalen-7-Yl]AcetamideN-[(7S)-3-Hydroxy-9-Keto-1,2-Di methoxy-10-(Methylthio)-6,7-Dihydro-5H-Benzo[D]Heptalen-7-Yl]Acetamide
- 3-Demethylthiocolchicine
- 3-Desmethylthiocolchicine
- 3-O-Demethylthiocolchicine
- Acetamide, N-[(7S)-5,6,7,9-tetrahydro-3-hydroxy-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]-
- Acetamide, N-[5,6,7,9-tetrahydro-3-hydroxy-1,2-dimethoxy- 10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]-, (S)-
- Benzo[a]heptalene, acetamide deriv.
- Colchicine, 2-demethylthio-
- N-[(7S)-5,6,7,9-Tetrahydro-3-hydroxy-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]acetamide
- NSC 361792
- Vedi altri sinonimi
3-Demethyl thiocolchicine is a potent inhibitor of the bacterial enzyme thiocolchicoside synthase. It inhibits the synthesis of thiocolchicoside, an intermediate in the biosynthesis of the cell wall component peptidoglycan. 3-Demethyl thiocolchicine has been shown to be active against L1210 murine leukemia cells and human leukemia cells in vitro. In addition, this compound has a strong inhibitory effect on tumor growth in mice. The mechanism may be due to its ability to induce apoptosis by inhibiting DNA synthesis and protein synthesis. 3-Demethyl thiocolchicine also has anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis.
Proprietà chimiche
Richiesta tecnica su: 3D-FD21016 3-Demethyl thiocolchicine
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