(5R,6S)-5,6-Diphenyl-2-morpholinone
CAS: 282735-66-4
Rif. 3D-FD46763
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Informazioni sul prodotto
- (5R,6S)-5,6-Diphenylmorpholin-2-one
- ((5R,6S)-2,3,5,6-tetrahydro-5,6- diphenyl-1,4-oxazin
(5R,6S)-5,6-Diphenyl-2-morpholinone is a synthetic compound that has been shown to inhibit the activity of the tumor suppressor protein MDM2. This agent is a potent inhibitor of MDM2 with IC50 values in the low μM range. It also inhibits other proteins that are important for cancer growth and development, including p53 and Rb. The synthesis of (5R,6S)-5,6-diphenyl-2-morpholinone was accomplished by an efficient one-pot method based on 1,3-dipolar cycloaddition chemistry. It has been crystallographically characterized using X-ray diffraction data collected at 100 K. The molecular structure reveals a planar molecule with two morpholine rings in close proximity to each other. The crystal packing suggests that there may be favorable interactions between the two morpholine rings and the surrounding solvent molecules. Additional studies will be required to confirm this
Proprietà chimiche
Richiesta tecnica su: 3D-FD46763 (5R,6S)-5,6-Diphenyl-2-morpholinone
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