Ethyl 6-bromo-4-chloroquinoline-3-carboxylate

CAS: 206257-39-8

Rif. 3D-FE130404

Informazioni sul prodotto

• Nome: Ethyl 6-bromo-4-chloroquinoline-3-carboxylate
• Sinonimi: 3-quinolinecarboxylic acid, 6-bromo-4-chloro-, ethyl ester, 3-Quinolinecarboxylic Acid, 6-Bromo-4-Chloro-, Ethyl Ester, Ethyl 6-bromo-4-chloro-3-quinolinecarboxylate

Descrizione

Ethyl 6-bromo-4-chloroquinoline-3-carboxylate is a drug that inhibits the activity of protein kinases. It has been shown to inhibit the activity of telangiectasia and is being investigated as a probe for medicinal chemistry. It is an analog of irinotecan, which inhibits the enzyme topoisomerase 1, leading to DNA damage. This drug also has potential as a cancer therapeutic because it is orally bioavailable and has been shown to be mutated in vivo, which may make it more effective at inhibiting tumor growth. Ethyl 6-bromo-4-chloroquinoline-3-carboxylate binds to ATP and prevents the release of ADP, which leads to inhibition of protein synthesis. This drug also inhibits tyrosine kinase activity by binding with carboxamides on the enzyme's active site.

• Marchio: Biosynth

Proprietà chimiche

• Peso molecolare: 314.56 g/mol
• Formula: C₁₂H₉BrClNO₂
• Purezza: Min. 95%
• InChI: InChI=1S/C12H9BrClNO2/c1-2-17-12(16)9-6-15-10-4-3-7(13)5-8(10)11(9)14/h3-6H,2H2,1H3
• InChI key: InChIKey=YGMLKBFPHVLHGT-UHFFFAOYSA-N
• SMILES: CCOC(=O)c1cnc2ccc(Br)cc2c1Cl