6-Ethyl-5-(4-Fluoro-3-Nitrophenyl)Pyrimidine-2,4-Diamine
CAS: 113494-35-2
Rif. 3D-FE94781
| Dimensione non definita | Fuori produzione |
Informazioni sul prodotto
Nome:
6-Ethyl-5-(4-Fluoro-3-Nitrophenyl)Pyrimidine-2,4-Diamine
Sinonimi:
- 4'-Fluoro-3'-nitropyrimethamine
- 4-Fnpm
- 2,4-Diamino-5-(4-fluoro-3-nitrophenyl)-6-ethylpyrimidine
Descrizione:
6-Ethyl-5-(4-fluoro-3-nitrophenyl)pyrimidine-2,4-diamine is an antifolate that inhibits the enzyme dihydrofolate reductase. The ligand binds to the target enzyme with a high affinity and the binding affinities of the two isomers are different. The enantiomeric mixture of 6-ethyl-5-(4-fluoro-3-nitrophenyl)pyrimidine-2,4-diamine has been shown to have potent antifolate activity against methotrexate resistant cells in vitro and in vivo. Spectroscopy studies have shown that this molecule exists as enantiomers, which can be interconverted by reductases (e.g., NADPH). The interconversion rate is dependent on the concentration of reductase and the pH of the solution. The conformational changes in the ligand are slow and are detectable
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Marchio:
Biosynth
Conservazione lunga:
Note:
Proprietà chimiche
Peso molecolare:
277.25 g/mol
Formula:
C12H12FN5O2
Purezza:
Min. 95%
MDL:
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