2-(Fluoromethyl)-Ornithine

CAS: 73800-85-8

Rif. 3D-FF78253

Informazioni sul prodotto

• Nome: 2-(Fluoromethyl)-Ornithine
• Sinonimi: Ornithine, 2-(Fluoromethyl)-

Descrizione

2-(Fluoromethyl)-Ornithine (2-FMEO) is a potent antitumor agent that is an irreversible inhibitor of polyamine biosynthesis. It has been shown to inhibit the growth of cancer cells and other tumor cells in experimental models. 2-FMEO inhibits the enzyme ornithine decarboxylase, which converts ornithine to putrescine, by binding reversibly to the nitrogen atom in the active site. This inhibition leads to a depletion of polyamines, which are necessary for cell growth. 2-FMEO also inhibits spermidine synthase and spermidine/spermine N1-acetyltransferase, which are enzymes involved in the synthesis of spermidine and spermine from putrescine.

• Marchio: Biosynth

Proprietà chimiche

• Peso molecolare: 164.18 g/mol
• Formula: C₆H₁₃FN₂O₂
• Purezza: Min. 95%
• InChI: InChI=1S/C6H13FN2O2/c7-4-6(9,5(10)11)2-1-3-8/h1-4,8-9H2,(H,10,11)
• InChI key: InChIKey=PYSFCFGTQFSVRE-UHFFFAOYSA-N
• SMILES: NCCCC(N)(CF)C(=O)O