3-Hydroxyacetaminophen
CAS: 37519-14-5
Rif. 3D-FH24299
5mg | Fuori produzione | ||
10mg | Fuori produzione | ||
25mg | Fuori produzione | ||
50mg | Fuori produzione | ||
100mg | Fuori produzione |
Informazioni sul prodotto
- N-(3,4-Dihdyroxyphenyl)acetamide4-Acetylaminopyrocatechol4-(Acetylamino)catechol
- 4-(Acetylamino)catechol
- 4-Acetylaminopyrocatechol
- Acetamide, N-(3,4-dihydroxyphenyl)-
- Acetanilide, 3′,4′-dihydroxy-
- N-(3,4-Dihydroxyphenyl)acetamide
3-Hydroxyacetaminophen is a reactive metabolite of acetaminophen. It is produced by the bacterial strain Acinetobacter calcoaceticus, which was found to produce 3-hydroxyacetaminophen in the presence of oxygen and nitrate. The production process can be optimized by using surface methodology and kinetic studies. In vitro assays showed that 3-hydroxyacetaminophen has a higher cytotoxicity than acetaminophen, as well as an inhibitory effect on tyrosinase activity. This may be due to the deuterium isotope effect, which causes a substitution of hydrogen with deuterium atoms. The reaction intermediates are not known, but they are thought to be generated by chemical reactions involving the substrate or other reactants.