3-Iodo-1H-pyrazole-4-carboxylic acid ethyl ester
CAS: 827316-43-8
Rif. 3D-FI74684
| 2g | 172,00 € | ||
| 5g | 232,00 € | ||
| 10g | 364,00 € | ||
| 25g | 582,00 € | ||
| 50g | 986,00 € |
Informazioni sul prodotto
Begaestat is a novel, orally active, small-molecule inhibitor of chymotrypsin-like activity in the human proteasome. It has been shown to be effective in inhibiting tumor cell growth and metastasis in animal models and has demonstrated clinical activity in phase I clinical trials. Begaestat inhibits the production of methylthioadenosine (MTA), which is an endogenous metabolite that can inhibit cancer cells. MTA inhibits the production of protein, leading to cell death by inhibiting protein synthesis and DNA replication. Begaestat also binds to a synthetic substrate that resembles the arginine site on the proteasome, thereby preventing the formation of an enzyme-substrate complex and inhibiting chymotrypsin-like activity.
Proprietà chimiche
Richiesta tecnica su: 3D-FI74684 3-Iodo-1H-pyrazole-4-carboxylic acid ethyl ester
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