2-Methylimidazo[1,2-a]pyridine-3-carboxylicacid
CAS: 21801-79-6
Rif. 3D-FM147594
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Informazioni sul prodotto
- 2-Methylimidazo[1,2-A]Pyridine-3-Carboxylate
- Imidazo[1,2-A]Pyridine-3-Carboxylic Acid, 2-Methyl-
- NSC 156822
2-Methylimidazo[1,2-a]pyridine-3-carboxylicacid is an anti-tuberculous agent that belongs to the class of rifampin. It is a pyridine derivative that inhibits bacterial growth by binding to DNA-dependent RNA polymerase and prevents transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Rifampin also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.
Proprietà chimiche
Richiesta tecnica su: 3D-FM147594 2-Methylimidazo[1,2-a]pyridine-3-carboxylicacid
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