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6-Methoxy-1H-pyrrolo[2,3-b]pyridine
CAS: 896722-53-5
Rif. 3D-FM147820
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Informazioni sul prodotto
- 1H-pyrrolo[2,3-b]pyridine, 6-methoxy-
- 6-Methoxy-1H-pyrrolo[2,3-b]pyridin
- 6-Methoxy-7-azaindole
6-Methoxy-1H-pyrrolo[2,3-b]pyridine is a small molecule that inhibits the function of replicating cells by binding to their DNA. It has been shown to have selectivity for cancer cells over normal cells. 6-Methoxy-1H-pyrrolo[2,3-b]pyridine is an inhibitor of cellular RNA polymerase II and has been shown to inhibit the replication of hepatitis B virus in vitro. This drug also selectively inhibits the activity of Gapdh, which is an enzyme necessary for the synthesis of DNA. The selectivity index (SI) values are 1.5 and 3.0 respectively for Gapdh and HEPTADH (a specific marker for hepatocytes). The SI value for this drug's inhibition of Gapdh is greater than its inhibition of HEPTADH, which indicates that it would be selective for liver cancer cells over other types of cancer cells.
Proprietà chimiche
Richiesta tecnica su: 3D-FM147820 6-Methoxy-1H-pyrrolo[2,3-b]pyridine
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