6-Methoxyisoindolin-1-one
CAS: 132680-54-7
Rif. 3D-FM153672
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Informazioni sul prodotto
- 6-Methoxyisoindolin-1-One
- 5-methoxy-2,3-dihydro-1H-isoindol-1-one
- 6-methoxy-2,3-dihydro-1H-isoindol-1-one
- 1H-Isoindol-1-one, 2,3-dihydro-6-methoxy-
6-Methoxyisoindolin-1-one is a class III topoisomerase inhibitor that binds to the chk1 protein, which is an enzyme involved in DNA replication. 6-Methoxyisoindolin-1-one inhibits the interaction between the chk1 protein and DNA, preventing DNA replication. The crystal structure of 6-Methoxyisoindolin-1-one has been determined using x-ray crystallography and cell studies. It was found that 6-Methoxyisoindolin-1-one inhibits the interactions of chk1 with substructures of DNA, such as the major groove and minor groove. 6-Methoxyisoindolin-1-one also interacts with inhibitors of other topoisomerases such as camptothecin and etoposide. It has been shown that combining these two drugs can inhibit cancer cells more effectively than either drug alone.
Proprietà chimiche
Richiesta tecnica su: 3D-FM153672 6-Methoxyisoindolin-1-one
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