4-Nitro-1,2,5-oxadiazol-3-amine
CAS: 66328-69-6
Rif. 3D-FN117558
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Informazioni sul prodotto
- 3-Amino-4-nitrofurazan
4-Nitro-1,2,5-oxadiazol-3-amine is a molecule that has been shown to be an inhibitor of the epidermal growth factor receptor (EGFR). The optimal reaction conditions for this molecule were determined by crystallography. These results were confirmed by prognosis assays and the determination of tautomers. This molecule may be used in diagnosis and as a potential treatment for cancer. 4-Nitro-1,2,5-oxadiazol-3-amine binds to the EGFR at a site different from that of erlotinib, an inhibitor currently used in the clinic. This binding leads to inhibition of protein synthesis and cell division by preventing the activation of downstream signal transduction pathways. The molecule also inhibits tumor cell proliferation and induces apoptosis by preventing the production of nitric oxide (NO) and reactive oxygen species (ROS).
Proprietà chimiche
Richiesta tecnica su: 3D-FN117558 4-Nitro-1,2,5-oxadiazol-3-amine
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