2-Nitrotoluene
CAS: 88-72-2
Rif. 3D-FN37154
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Informazioni sul prodotto
- ortho-Nitrotolueneo-Nitrotoluene
- 1-Methyl-2-nitrobenzene
- 2-Methyl-1-nitrobenzene
- 2-Methylnitrobenzene
- 2-Nitrotolueno
- 2-Nitrotoluol
- Benzene, 1-methyl-2-nitro
- Nsc 9577
- Ortho Nitrotoluene
- Toluene, 2-Nitro-
- Vedi altri sinonimi
- Toluene, o-nitro-
- o-Methylnitrobenzene
- o-Mononitrotoluene
- o-Nitrotoluene
2-Nitrotoluene is a nitro compound that is carcinogenic and has been shown to produce liver lesions in experimental animals. It is an acidic, water-soluble liquid with a molecular weight of 114.17 g/mol. 2-Nitrotoluene has been shown to react with DNA polymerase II's α subunit, which leads to the inhibition of DNA synthesis and cell death. The reaction mechanism involves the formation of intramolecular hydrogen bonds between the nitro group on one molecule of 2-nitrotoluene and the deoxyribose sugar on another molecule. These intramolecular hydrogen bonds lead to a distortion in the shape of DNA polymerase II's α subunit, which prevents it from binding to DNA and hence inhibits its ability to synthesize new DNA strands. 2-Nitrotoluene also reacts with cellular proteins and lipid bilayers, leading to cell death by necrosis or apoptosis.
Proprietà chimiche
Richiesta tecnica su: 3D-FN37154 2-Nitrotoluene
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