Quinocetone
CAS: 81810-66-4
Rif. 3D-FQ33529
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Informazioni sul prodotto
- 1-(3-Methyl-1,4-dioxido-2-quinoxalinyl)-3-phenyl-2-propen-1-one
- 1-(3-Methyl-2-quinoxalinyl)-3-phenyl-2-propen-1-one N,N'-dioxide
- 2-Propen-1-one, 1-(3-methyl-1,4-dioxido-2-quinoxalinyl)-3-phenyl-
- 2-Propen-1-one, 1-(3-methyl-2-quinoxalinyl)-3-phenyl-, N,N′-dioxide
- NSC 621477
Quinocetone is a novel synthetic compound that has significant cytotoxicity and genotoxic effects. It has been found to inhibit the activity of DNA polymerase, mitochondrial membrane potential, and quinocetone reductase in the presence of sodium carbonate. Quinocetone also inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Rifapentine also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.
Proprietà chimiche
Richiesta tecnica su: 3D-FQ33529 Quinocetone
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