Informazioni sul prodotto
The in vivo activity of 8-fluoro-1-naphthoic acid has been shown to be CB2 receptor mediated. It was found to have a high affinity for the CB2 receptor, with an EC50 value of 0.5 nM. The electron affinities and substituents were also found to be important for the binding of 8-fluoro-1-naphthoic acid to the CB2 receptor, with bromo substituents being most effective.
8-Fluoro-1-naphthoic acid is an analog of 2-(4'-chlorobiphenyl)-N-(piperidin-1-yl)ethanamine (JWH133), which binds with high affinity to the cannabinoid receptor CB2 and is a potent agonist at this site, but not at the cannabinoid receptor CB1. 8FNA acts as an agonist at both receptors, but it has higher affinity for the
Proprietà chimiche
Richiesta tecnica su: 3D-FRA19633 8-Fluoro-1-naphthoic acid
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