5-(4-Tolylthio)-2,4-diaminoquinazoline

CAS: 168910-32-5

Rif. 3D-FT28325

Informazioni sul prodotto

• Nome: 5-(4-Tolylthio)-2,4-diaminoquinazoline
• Sinonimi: 5-[(4-Methylphenyl)thio]-2,4-quinazolinediamine, 5-[(4-Methylphenyl)Thio]Quinazoline-2,4-Diamine

Descrizione

5-(4-Tolylthio)-2,4-diaminoquinazoline is a β-glucocerebrosidase inhibitor. It is an enzyme that breaks down glucosylceramide and other glycosphingolipids in the lysosomes of cells. Deficiency of this enzyme is associated with Gaucher's disease, which is a rare metabolic disorder characterized by the accumulation of glucocerebroside in tissues and organs. 5-(4-Tolylthio)-2,4-diaminoquinazoline has been shown to be active at subinhibitory concentrations against macrophages and to have beneficial effects on Gaucher mice models. This drug also has a therapeutic effect on Gaucher mice models and could be used as an agent for treatment of Gaucher's disease.

• Marchio: Biosynth

Proprietà chimiche

• Peso molecolare: 282.36 g/mol
• Formula: C₁₅H₁₄N₄S
• Purezza: Min. 95%
• Colore/Forma: Powder
• InChI: InChI=1S/C15H14N4S/c1-9-5-7-10(8-6-9)20-12-4-2-3-11-13(12)14(16)19-15(17)18-11/h2-8H,1H3,(H4,16,17,18,19)
• InChI key: InChIKey=UOJFGEAPSYQDIP-UHFFFAOYSA-N
• SMILES: Cc1ccc(Sc2cccc3nc(N)nc(N)c23)cc1