Informazioni sul prodotto
2-hydroxy-4-pyrrol-1-yl-benzoic acid (HPABA) is a postulated structure-based drug that has been shown to inhibit the bacterial enzyme, 2,4-diaminopyrimidine deaminase (DAP). HPABA is an amide and analog of the natural substrate of DAP. It inhibits DAP by competitive inhibition at the active site. The dose of HPABA required for inhibition is dependent on the concentration of DAP in the cell. The low molecular weight and lipophilic properties of HPABA allow it to cross cellular membranes easily. This compound also has pharmacokinetic properties that make it an ideal candidate for use as a chemotherapeutic agent. HPABA is metabolized into reactive intermediates by cytochrome P450 enzymes and glutathione S transferases, which have been shown to cause DNA damage and cytotoxicity in cancer cells. These metabolites are further metabol
Proprietà chimiche
Richiesta tecnica su: 3D-KBA58052 2-Hydroxy-4-pyrrol-1-yl-benzoic acid
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