(-)-2'-Deoxy-3'-oxa-4'-thiocytidine (apricitabine)
CAS: 160707-69-7
Rif. 3D-KGA70769
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Informazioni sul prodotto
- (-)-2′-Deoxy-3′-oxa-4′-thiocytidine
- (-)-Bch 10652
- 1,3-Oxathiolane, 2(1H)-pyrimidinone deriv.
- 2(1H)-Pyrimidinone, 4-amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-
- 2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-, (2R-cis)-
- 4-Amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-2(1H)-pyrimidinone
- Avx 754
- Bch 10618
- Spd 754
Apricitabine is a nucleoside analog that has been shown to be active against HIV. It inhibits HIV-1 reverse transcriptase by competing with the natural substrate, deoxycytidine triphosphate, and thereby prevents RNA synthesis. Apricitabine can be used for treatment of chronic hepatitis B or C virus infections, as well as long-term therapy for HIV infection. The drug has shown long-term efficacy in reducing viral load in patients receiving antiretroviral therapy, without causing significant toxicity. Apricitabine is not metabolized by cytochrome P450 enzymes and does not have significant interactions with other drugs. The drug binds to DNA in the cell nucleus and inhibits the process of DNA replication. The clinical use of apricitabine is limited by its short half-life (approximately 1 hour), which requires intravenous administration twice daily.
Proprietà chimiche
Richiesta tecnica su: 3D-KGA70769 (-)-2'-Deoxy-3'-oxa-4'-thiocytidine (apricitabine)
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