ML417
CAS: 1386162-69-1
Rif. 3D-LFC16269
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Informazioni sul prodotto
ML417 is a novel, non-peptide, high-affinity dopamine D2 receptor agonist that has been shown to be a potent functional ligand in the rat and monkey. It has been shown to increase dopamine levels in the central nervous system. ML417 also blocks the binding of [3H]spiperone to the human D2 receptor with an affinity similar to that of quinpirole (a reference high-affinity D2 receptor agonist). The compound has been shown to have clinical relevance in animal models of myocardial infarct and in behavioral assays for antipsychotic activity. In vitro studies have revealed that ML417 has biochemical properties consistent with those observed for other dopamine receptor ligands. These include binding to d2/d3 receptors and inhibition of adenylyl cyclase activity. Molecular modeling studies have demonstrated that ML417 is a high-affinity molecule for the dopamine D2 receptor with a favorable pharmacokinetic profile.
Proprietà chimiche
Richiesta tecnica su: 3D-LFC16269 ML417
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