Informazioni sul prodotto
- Tris-β-GalNAc-GABA-PEG-PhospholipidTriantennary β-D-GalNAc-GABA-PEG-phospholipidTri-GalNAc-PEG2000-DSPE(β-D-GalNAc-sp)3-NHC(O)-GA BA-PEG2k-phospholipid1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[tris-GalNAc-GABA-(polyethylene glycol)-2000Tris
Tri-b-GalNAc-PEG2000 is a multivalent ligand containing three GalNAc moieties linked to a polyethylene glycol (PEG) spacer designed to selectively bind to the asialoglycoprotein receptor (ASGPR) expressed on hepatocytes. It can be used to create targeted drug delivery vehicles, such as liposomes or lipid nanoparticles, that specifically deliver therapeutic agents to the liver. The multivalent GalNAc ligands have high affinity for ASGPR, allowing for enhanced accumulation of drugs in the target organ while minimizing exposure to non-target tissues. The compound is typically conjugated to a phospholipid, such as 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE), to create DSPE-PEG2000-triGalNAc. This lipid-based construct can be readily incorporated into liposomes or lipid nanoparticles during formulation, enabling the development of targeted drug delivery systems.
Proprietà chimiche
Richiesta tecnica su: 3D-MT184256 DSPE-PEG2000-Tri-b-GalNAc
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