2'-Cyano-2'-deoxy-1-(b-D-arabinofuranosyl)cytosine
CAS: 135598-68-4
Rif. 3D-NC29827
Dimensione non definita | Prezzo su richiesta |
Informazioni sul prodotto
2'-Cyano-2'-deoxy-1-(b-D-arabinofuranosyl)cytosine is an analog of the natural substrate for DNA cytosine methyltransferase, 5-methylcytosine. 2'-Cyano-2'-deoxy-1-(b-D-arabinofuranosyl)cytosine inhibits the enzyme activity of DNA methyltransferase and blocks cell proliferation. It has been shown to be a potent antitumor agent in experimental models and may serve as a potential biomarker for cancer treatment. The drug is an oral prodrug that is activated by deamination in the liver and kidneys to release the active form, 5'-Azacytidine monophosphate (5'AZA). This metabolite then inhibits DNA methylation by binding to DNA cytosine methyltransferase, resulting in a loss of function of this enzyme.
Proprietà chimiche
Richiesta tecnica su: 3D-NC29827 2'-Cyano-2'-deoxy-1-(b-D-arabinofuranosyl)cytosine
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