GD2-Ganglioside
CAS: 65988-71-8
Rif. 3D-OG06830
| 1mg | 1.757,00 € | ||
| 50µg | 451,00 € | ||
| 100µg | 592,00 € | ||
| 200µg | 906,00 € | ||
| 500µg | 1.436,00 € |
Informazioni sul prodotto
- Disialoganglioside-GD2
- 65988-71-8
- Disialoganglioside GD<sub>2</sub>
- G<sub>D2</sub>
- Ganglioside G<sub>D2</sub>
GD2 (shown as sodium salt) has a core trisaccharide structure (GalNAc-b-1,4-Gal-b-1,4-Glc) with its two sialic acids linked b-2,3/b-2,8 to the inner galactose residue and ceramide linked to position 1 on the reducing terminal glucose residue. GD2 ganglioside is expressed at a low concentration in the central nervous system, nerves, skin melanocytes and stem cells in healthy adults. On the other hand, GD2 is overexpressed in a number of tumors, including: neuroblastoma, melanoma, small cell lung carcinoma and brain tumors. Recently, it has been found in low concentrations on breast cancer stem cells (CSC) that possess: self-renewal properties (division without disrupting the undifferentiated state), and tumor-initiating capabilities. It has been suggested that GD2 ganglioside may be developed as an effective target antigen for CSC immunotherapy (Fleurence, 2017).
Proprietà chimiche
Richiesta tecnica su: 3D-OG06830 GD2-Ganglioside
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