Informazioni sul prodotto
- 4-Ammonio-3,3-Dimethylbutanoate
- Butanoic acid, 4-amino-3,3-dimethyl-
4-Amino-3,3-dimethylbutanoic acid is a prodrug that has a carbonyl group and three methyl groups. The conjugate is thermodynamically stable and the interaction between the benzyl esters and proton is site specific. The prodrug is hydrolyzed stepwise by β-lactamase to release paclitaxel. 4-Amino-3,3-dimethylbutanoic acid has been used as a linker for paclitaxel to increase its stability in plasma and improve its water solubility. It also produces ester hydrochloride of paclitaxel, which can be titrated to produce a desired concentration of drug in plasma.
Proprietà chimiche
Richiesta tecnica su: 3D-PDA58422 4-Amino-3,3-dimethylbutanoic acid
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