(-)-U-50488 Hydrochloride
CAS: 114528-79-9
Rif. 3D-PEA52879
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Informazioni sul prodotto
- Benzeneacetamide,3,4-dichloro-N-methyl-N-[(1S,2S)-2-(1-pyrrolidinyl)cyclohexyl]-,monohydrochloride (9CI)
- Benzeneacetamide,3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-, monohydrochloride,(1S-trans)-
(-)-U-50488 is an opioid drug that binds to the receptor in the central nervous system and inhibits adenylyl cyclase. This inhibition prevents the conversion of ATP into cAMP, which leads to a decrease in intracellular calcium ion concentration. (-)-U-50488 increases the production of calcitonin gene-related peptide (CGRP) by binding to calcitonin receptors in the brain, which creates analgesic effects. It also has a number of other mechanisms that affect various cell signaling pathways and neurotransmitter systems. These effects include inhibiting signal-regulated kinase (SRC), activation of extracellular 5-hydroxytryptamine receptors, and upregulation of cyclase activity. (-)-U-50488 may be useful for treating neuropathic pain, but it has not been approved for this use by the U.S. Food and Drug Administration.
Proprietà chimiche
Richiesta tecnica su: 3D-PEA52879 (-)-U-50488 Hydrochloride
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