HLA leader peptide LVL
Rif. 3D-PP45242
1mg
226,00€
10mg
263,00€
100mg
473,00€
Informazioni sul prodotto
Nome:HLA leader peptide LVL
Sinonimi:
- H-VMAPRTLVL-OH NH2-Val-Met-Ala-Pro-Arg-Thr-Leu-Val-Leu-OH
Marchio:Biosynth
Descrizione:Fragment of the signal peptide from endogenous HLA Class I molecules which is also found in viral glycoproteins, for example human Cytomegalovirus (hCMV) protein UL40.
When presented on a cell surface via HLA-E molecules, the HLA- VMAPRTLVL complex binds NKG2A receptors on Natural Killer (NK) cells and some CD8⁺ cytotoxic T cells to reduce their cytotoxic activity. Blocking this interaction is an attractive opportunity for immune checkpoint (IC) approach therapies. This is relevant in both cancer therapies, and viral infections, where endogenous HLA Class I peptide presentation is exploited to escape immune attack.In one study, VMAPRTLVL UL4015-23 was found in 18% congenital cytomegalovirus (cCMV) strains.
When presented on a cell surface via HLA-E molecules, the HLA- VMAPRTLVL complex binds NKG2A receptors on Natural Killer (NK) cells and some CD8⁺ cytotoxic T cells to reduce their cytotoxic activity. Blocking this interaction is an attractive opportunity for immune checkpoint (IC) approach therapies. This is relevant in both cancer therapies, and viral infections, where endogenous HLA Class I peptide presentation is exploited to escape immune attack.In one study, VMAPRTLVL UL4015-23 was found in 18% congenital cytomegalovirus (cCMV) strains.
Avviso:I nostri prodotti sono destinati esclusivamente ad uso di laboratorio. Per qualsiasi altro utilizzo, vi preghiamo di contattarci.
Proprietà chimiche
Richiesta tecnica su: HLA leader peptide LVL
Si prega di utilizzare piuttosto il carrello per richiedere un preventivo o un ordine
Si prega di utilizzare piuttosto il carrello per richiedere un preventivo o un ordine. Se si desidera richiedere un preventivo o effettuare un ordine, si prega invece di aggiungere i prodotti desiderati al carrello e poi richiedere un preventivo o un ordine dal carrello. È più veloce, più economico, e potrà beneficiare degli sconti disponibili e di altri vantaggi.