N-(4-(Diethylaminobenzylidenyl)-N'-(4-hydroxybenzoyl)-hydrazine
CAS: 95167-41-2
Rif. 3D-VDA16741
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Informazioni sul prodotto
- Benzoic acid, 4-hydroxy-, [[4-(diethylamino)phenyl]methylene]hydrazide (9CI)
- Benzoic acid, 4-hydroxy-, 2-[(1E)-[4-(diethylamino)phenyl]methylene]hydrazide
- N'-{(E)-[4-(Diethylamino)phenyl]methylene}-4-hydroxybenzohydrazide
- N'-{(E)-[4-(diethylamino)phenyl]methylidene}-4-hydroxybenzohydrazide
N-(4-(Diethylaminobenzylidenyl)-N'-(4-hydroxybenzoyl)-hydrazine (MDL-28170) is a small molecule that inhibits the activity of nuclear factor-κB (NF-κB), which is a transcriptional activator of genes. It has been shown to regulate cell function and regression, as well as markers activated by NF-κB in the mitochondria, endoplasmic reticulum, and nucleus. MDL-28170 inhibits the activation of NF-κB in animal models and induces histologic regression in rats with induced prostate cancer. This agent also displays antiestrogenic effects by inhibiting the expression of estrogen receptors alpha and beta.
Proprietà chimiche
Richiesta tecnica su: 3D-VDA16741 N-(4-(Diethylaminobenzylidenyl)-N'-(4-hydroxybenzoyl)-hydrazine
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