GSK-239512
CAS: 720691-69-0
Rif. 3D-VDB69169
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Informazioni sul prodotto
GSK-239512 is a clinical candidate for the treatment of chronic inflammatory diseases. It is a potent antagonist of the IL-6 receptor and has been shown to have immunomodulatory effects in preclinical models. GSK-239512 has been studied in an oral chronic toxicity study in rats at doses of up to 600 mg/kg/day for 18 months, with no evidence of any toxic effect. The drug was not found to cross the blood-brain barrier or cause any effect on the central nervous system. In molecular modeling studies, GSK-239512 was found to bind to IL-6 receptors and block signaling pathways associated with inflammation, including those that lead to neutrophil recruitment, endothelial activation and platelet aggregation.
GSK-239512 has been shown to be safe at doses up to 600 mg/kg/day in nonclinical studies and was well tolerated by animals at doses up to 600 mg/kg/day in a long term
Proprietà chimiche
Richiesta tecnica su: 3D-VDB69169 GSK-239512
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