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PF 04449913
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PF 04449913

CAS: 1095173-27-5

Rif. 3D-VTB17327

5mgFuori produzione
10mg
Fuori produzione
25mgFuori produzione
50mgFuori produzione
100mg
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Informazioni sul prodotto

Nome:
PF 04449913
Sinonimi:
  • 1-((2R,4R)-2-(1H-Benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea
  • Glasdegib
  • N-[(2R,4R)-2-(1H-Benzimidazol-2-yl)-1-methyl-4-piperidinyl]-N′-(4-cyanophenyl)urea
  • Urea, N-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methyl-4-piperidinyl]-N′-(4-cyanophenyl)-
Descrizione:

PF 04449913 is a potent inhibitor of the enzyme caspase-3. It has been shown to have long-term efficacy and good tolerability in phase II clinical trials. PF 04449913 interacts with cell factor, a protein that is involved in the regulation of cell growth, differentiation, and apoptosis. This inhibition leads to inhibition of myeloid leukemia cells, which are important for the production of white blood cells and platelets in the body. PF 04449913 also inhibits Toll-like receptor signaling pathways that are activated by microbial products such as lipopolysaccharide (LPS). In vivo models have shown PF 04449913 to be well tolerated at doses up to 150 mg/kg/day and to reduce tumor size in mouse xenografts.

Avviso:
I nostri prodotti sono destinati esclusivamente ad uso di laboratorio. Per qualsiasi altro utilizzo, vi preghiamo di contattarci.
Marchio:
Biosynth
Conservazione lunga:
Note:

Proprietà chimiche

Peso molecolare:
374.45 g/mol
Formula:
C21H22N6O
Purezza:
Min. 95%
MDL:
Punto di fusione:
Punto di ebollizione:
Punto di infiammabilità:
Densità:
Concentrazione:
EINECS:
Merck:
Codice SA:

Informazioni sui pericoli

Numero ONU:
EQ:
Classe:
Indicazioni di pericolo:
Consigli di prudenza:
Vietato trasportare in aereo:
Informazioni sui pericoli:
Gruppo di imballaggio:
LQ:

Richiesta di informazioni sul prodotto fuori produzione: 3D-VTB17327 PF 04449913

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