Huntingtin (phospho Ser421) rabbit pAb
Rif. EK-ES5727
| 50µl | 188,00 € | ||
| 100µl | 316,00 € |
Informazioni sul prodotto
- HTT; HD; IT15; Huntingtin; Huntington disease protein; HD protein
huntingtin(HTT) Homo sapiens Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range of trinucleotide repeats (9-35) has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widel
Proprietà chimiche
Richiesta tecnica su: EK-ES5727 Huntingtin (phospho Ser421) rabbit pAb
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