8-Chloroadenosine

CAS: 34408-14-5

Rif. TM-T19661

Informazioni sul prodotto

• Nome: 8-Chloroadenosine
• Sinonimi: NSC 354258, 8-Cl-Ado, NSC354258, NSC-354258
• CAS: 34408-14-5

Descrizione

8-Chloroadenosine (NSC-354258) is a 5' AMP-activated protein kinase agonist potentially for the treatment of chronic lymphocytic leukemia. 8-chloroadenosine activity is associated with inhibition of the mTOR pathway.8-Chloroadenosine (NSC-354258) is a nucleoside analog; metabolized in vivo to 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226, and U266 cancer cell lines; induces G2/M cell cycle arrest and mitotic catastrophe in A549 and H1299 cells. 8-Chloroadenosine (NSC-354258) has been shown to deplete ATP and inhibit tumor growth in hematological malignancies as well as in lung and breast cancer cell lines.

• Marchio: Targetmol

Proprietà chimiche

• Peso molecolare: 301.69
• Formula: C₁₀H₁₂ClN₅O₄
• Purezza: 99.48%
• Colore/Forma: Solid