Notch 3 Protein, Human, Recombinant (His)

Rif. TM-TMPK-01396

Informazioni sul prodotto

• Nome: Notch 3 Protein, Human, Recombinant (His)
• Sinonimi: NOTCH3, CADASIL, Notch-3, Notch homolog 3

Descrizione

Human Notch-3 is part of the Notch family of type I transmembrane glycoproteins involved in a number of early-event developmental processes. The extracellular domain of Notch receptors interact with the extracellular domain of transmembrane ligands Jagged, Delta, and Serrate expressed on the surface of a neighboring cell. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.

• Marchio: Targetmol

Proprietà chimiche

• Peso molecolare: 30.18 kDa (predicted). Due to furin-like protease cleavage and glycosylation, the protein migrates to 27-30 kDa and 10-12 kDa based on Tris-Bis PAGE result.
• Colore/Forma: Solid