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FKBP14 Protein, Human, Recombinant (His)
Rif. TM-TMPY-03385
100µg | 400,00 € |
Informazioni sul prodotto
- IPBP12, EDSKMH, FK506 binding protein 14, 22 kDa, FKBP22
FKBP14 belongs to the FK506-binding protein family. It contains 2 EF-hand domains and one PPIase FKBP-type domain. FKBP14 can be detected in the lumen of the endoplasmic reticulum where it is thought to accelerate the folding of proteins during protein synthesis. Truncation of the amino-terminus of FKBP14 significantly decreases peptidyl prolyl cis-trans isomerase activity, therefore implicating that the PPIase FKBP-type domain must be located at the N-terminus. Defects in FKBP14 can cause Ehlers-Danlos syndrome with progressive kyphoscoliosis, myopathy, and hearing loss. A syndrome with features of Ehlers-Danlos syndrome types VIA and VIB on the one hand, and the collagen VI-related congenital myopathies Ullrich congenital muscular dystrophy and Bethlem myopathy on the other hand.
Proprietà chimiche
Richiesta tecnica su: TM-TMPY-03385 FKBP14 Protein, Human, Recombinant (His)
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