Informazioni sul prodotto
- 3-Acetamidophthalic Anhydride
- 3-Acetamidophthalic anhydride
- NSC 16261
- NSC 17048
- acetamide, N-(1,3-dihydro-1,3-dioxo-4-isobenzofuranyl)-
- 1,3-Dioxo-2-isoindolineacetic acid
Impurity Apremilast Impurity 2
Stability Moisture Sensitive
Applications 3-Acetylaminophthalic Anhydride is used in the synthesis of Apremilast, a potent phosphodiesterase 4 and tumor necrosis Factor-α inhibitor used in the treatment of psoriatic arthritis. Also a reagent in the preparation of Tillivalline. Apremilast Impurity 2
References Man, H. et al.: J. Med. Chem., 52, 1522 (2009); Nagasaka, T. et al.: J. Org. Chem., 63, 697 (1998);