3,4-Bis((tert-butyldimethylsilyl)oxy) Estrone 1-N3-Adenine

Rif. TR-B415793

Informazioni sul prodotto

• Nome: 3,4-Bis((tert-butyldimethylsilyl)oxy) Estrone 1-N3-Adenine
• Sinonimi: (8R,9S,13S,14S)-1-(6-Amino-4,7-dihydro-3H-purin-3-yl)-3,4-bis((tert-butyldimethylsilyl)oxy)-13-methyl-7,8,9,11,12,13,15,16-octahydro-6H-cyclopenta[a]phenanthren-17(14H)-one

Descrizione

Applications 3,4-Bis((tert-butyldimethylsilyl)oxy) Estrone 1-N3-Adenine is an intermediate in the synthesis of 4-Hydroxy Estrone 1-N3-Adenine which is an estrogen metabolite formed with DNA which can lead to the mutations that initiate breast, prostate, and other types of cancer. The N3Ade depurinating adducts could serve as biomarkers to predict the risk of breast cancer.
References Chakravarti, D., et al.: Mutat. Res., 456, 17 (2000), Liehr, J., et al.: Endocr. Rev., 21, 4054 (2000), Chakravarti, D., et al.: Oncogene, 20, 7945 (2001), Cavalieri, E., et al.: Chem. Res. Toxicol., 14, 1041 (2002),

• Marchio: TRC

Proprietà chimiche

• Peso molecolare: 534.71
• Formula: C₃₅H₅₅N₅O₃Si₂
• Colore/Forma: Light Green
• InChI: InChI=1S/C24H46N4O7S/c25-7-3-9-31-11-13-33-15-17-35-18-16-34-14-12-32-10-4-8-26-22(29)6-2-1-5-21-23-20(19-36-21)27-24(30)28-23/h20-21,23H,1-19,25H2,(H,26,29)(H2,27,28,30)/t20-,21-,23-/m0/s1
• InChI key: InChIKey=AAPRTYNXINRWDQ-FUDKSRODSA-N
• SMILES: NCCCOCCOCCOCCOCCOCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12