1-[2-[(4-Chloro-2,5-dimethylphenyl)thio]phenyl]-piperazine

CAS: 2514952-66-8

Rif. TR-C371580

Informazioni sul prodotto

• Nome: 1-[2-[(4-Chloro-2,5-dimethylphenyl)thio]phenyl]-piperazine
• Sinonimi: 1-[2-[(4-Chloro-2,5-dimethylphenyl)thio]phenyl]piperazine (ACI)
• CAS: 2514952-66-8

Descrizione

Applications 1-[2-[(4-Chloro-2,5-dimethylphenyl)thio]phenyl]-piperazine is an intermediate in the synthesis of 3-Chloro-Vortioxetine which is an impurity of Vortioxetine (V766000), a multimodal serotonergic agent. Vortioxetine inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT.
References Bang-Andersen, B., et al.: J. Med. Chem., 54, 3206 (2011); Mørk, A., et al.: J. Pharmacol. Exp. Ther., 340, 666 (2012); Mørk, A., et al.: Pharmacol. Biochem. Behav. 105C, 41 (2013)

• Marchio: TRC

Proprietà chimiche

• Peso molecolare: 332.89
• Formula: C₁₈H₂₁ClN₂S
• Colore/Forma: Beige Solid
• InChI: InChI=1S/C18H21ClN2S/c1-13-12-18(14(2)11-15(13)19)22-17-6-4-3-5-16(17)21-9-7-20-8-10-21/h3-6,11-12,20H,7-10H2,1-2H3
• InChI key: InChIKey=XBCXJKGHPABGSD-UHFFFAOYSA-N
• SMILES: Cn1ccc(=O)[nH]c1=O