2-Deoxy-2-fluoro-a-D-arabinofuranosyl Bromide 3,5-Dibenzoate

CAS: 97614-44-3

Rif. TR-D235495

Informazioni sul prodotto

• Nome: 2-Deoxy-2-fluoro-a-D-arabinofuranosyl Bromide 3,5-Dibenzoate
• Sinonimi: 2-Deoxy-2-fluoro-alpha-D-arabinofuranosyl Bromide Dibenzoate, 2-Deoxy-1-α-bromo-2-β-fluoro-3,5-di-O-benzoyl-<span class="text-smallcaps">D</span>-ribofuranose, 2-Deoxy-2-Fluoro-Alpha-D-Arabinofuranosyl Bromide 3,5-Dibenzoate, 2-Deoxy-3,5-di-O-benzoyl-2-fluoro-a-D-arabinofuranosyl bromide, α-<span class="text-smallcaps">D</span>-Arabinofuranosyl bromide, 2-deoxy-2-fluoro-, 3,5-dibenzoate, α-<span class="text-smallcaps">D</span>-Arabinofuranosyl bromide, 2-deoxy-2-fluoro-, dibenzoate, α-D-Arabinofuranosyl bromide, 2-deoxy-2-fluoro-, 3,5-dibenzoate, 2-Deoxy-1-α-bromo-2-β-fluoro-3,5-di-O-benzoyl-D-ribofuranose, α-D-Arabinofuranosyl bromide, 2-deoxy-2-fluoro-, dibenzoate

Descrizione

Applications 2-Deoxy-2-fluoro-α-D-arabinofuranosyl Bromide 3,5-Dibenzoate, can be used in the synthesis of Clofarabine (C586890), which is a second generation purine nucleoside analog. It is also an antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Antineoplastic.
References Yaodong, Y., et al.: Jiefangjun Yaoxue Xuebao, 28, 218 (2012); Gandhi, V., et al.: Clin. Cancer Res., 9, 6335 (2003);

• Marchio: TRC

Proprietà chimiche

• Peso molecolare: 423.23
• Formula: C₁₉H₁₆BrFO₅
• InChI: InChI=1S/C19H16BrFO5/c20-17-15(21)16(26-19(23)13-9-5-2-6-10-13)14(25-17)11-24-18(22)12-7-3-1-4-8-12/h1-10,14-17H,11H2/t14-,15+,16-,17+/m1/s1
• InChI key: InChIKey=YYVZPZJEMLBIGM-TWMKSMIVSA-N
• SMILES: O=C(OC[C@H]1O[C@H](Br)[C@@H](F)[C@@H]1OC(=O)c1ccccc1)c1ccccc1