(alphaR)-7,8-Dihydro-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethanamine

CAS: 802918-35-0

Rif. TR-D455330

Informazioni sul prodotto

• Nome: (alphaR)-7,8-Dihydro-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethanamine
• Sinonimi: N-[(1R)-1-(7,8-dihydronaphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine

Descrizione

Applications (αR)-7,8-Dihydro-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethanamine is synthetically prepared though a double bond migration in Heck reaction during the preparation of cinacalcet congeners. This enantiomerically pure material is seperated from its counter part, (αR)-5,6-Dihydro-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethanamine (D455335) using HPLC.
References Wang, X., et al.: Tetrahedron Lett., 45, 8355 (2004)

• Marchio: TRC

Proprietà chimiche

• Peso molecolare: 359.428
• Formula: C₂₂H₂₄F₃N
• Colore/Forma: Neat
• InChI: InChI=1S/C22H24F3N/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25/h2,4-5,7,9-11,13,15-16,26H,3,6,8,12,14H2,1H3/t16-/m1/s1
• InChI key: InChIKey=VPQWHHXHXLLCGV-MRXNPFEDSA-N
• SMILES: C[C@@H](NCCCc1cccc(C(F)(F)F)c1)c1cccc2c1CCC=C2