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[5-(4-Fluorophenyl)-2-thienyl][2-methyl-5-(2,3,4,6-tetra-O-acetyl-Beta-D-glucopyranosyl)phenyl]-methanol
Rif. TR-F596745
| 5mg | Fuori produzione | ||
| 10mg | Fuori produzione | ||
| 25mg | Fuori produzione |
Informazioni sul prodotto
Nome:
[5-(4-Fluorophenyl)-2-thienyl][2-methyl-5-(2,3,4,6-tetra-O-acetyl-Beta-D-glucopyranosyl)phenyl]-methanol
Descrizione:
Applications [5-(4-Fluorophenyl)-2-thienyl][2-methyl-5-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)phenyl]-methanol is an intermediate in the synthesis of Canagliflozin which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity.
References Chao, E. et al.: Drug Fut., 36, 351 (2011); Sha, S. et al.: Diab. Obes. Metab., 13, 669 (2011); Kipnes, M.S.: Clin. Invest., 1, 145 (2011);
Avviso:
I nostri prodotti sono destinati esclusivamente ad uso di laboratorio. Per qualsiasi altro utilizzo, vi preghiamo di contattarci.
Marchio:
TRC
Conservazione lunga:
Note:
Proprietà chimiche
Peso molecolare:
628.66
Formula:
C32H33FO10S
Colore/Forma:
White Solid
InChI:
InChI=1S/C32H32N4O7/c1-39-23-13-9-21(10-14-23)32(20-7-5-4-6-8-20,22-11-15-24(40-2)16-12-22)42-17-25-27(37)28(41-3)31(43-25)36-19-35-26-29(36)33-18-34-30(26)38/h4-16,18-19,25,27-28,31,37H,17H2,1-3H3,(H,33,34,38)/t25-,27?,28?,31-/m1/s1
InChI key:
InChIKey=KXFBGUCGEWPHRA-KYXVNQOUSA-N
SMILES:
COc1ccc(C(OC[C@H]2O[C@@H](n3cnc4c(=O)nc[nH]c43)C(OC)C2O)(c2ccccc2)c2ccc(OC)cc2)cc1
MDL:
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