1-Glycidylpiperidine

CAS: 4945-53-3

Rif. TR-G582385

Informazioni sul prodotto

• Nome: 1-Glycidylpiperidine
• Sinonimi: 1-(2,3-Epoxypropyl)-piperidine, 1-(Oxiranylmethyl)-piperidine, 1-(2-Oxiranylmethyl)piperidine, 1,2-Epoxy-3-(1-piperidinyl)propane, 1-(Oxiranylmethyl)piperidine, 1-[(Oxiran-2-yl)methyl]piperidine, 3-Piperidinopropylene Oxide, N-(2,3-Epoxypropyl)piperidine

Descrizione

Applications 1-Glycidylpiperidine is an intermediate in the synthesis of BGP 15 (B411990). BGP 15 is a calcipotriene-based vitamin D3 analog that inhibits poly(ADP-ribose) polymerasesis (PARP), a class of enzymes that regulate DNA repair and apoptosis (1). BGP 15 is also a cardioprotective agent (2). Also, BPG 15 improves mitochondrial function, protects neurons from dying in vitro and in vivo, and promotes cardiac innervation in vivo.
References Sarszegi, Z., et al.: Mol. Cell. Biol., 365, 129-137 (2012); Ohlen, S. B., et al.: Proc. Natl. Acad. Sci. U.S.A., 114, 5035-5040 (2017)

• Marchio: TRC

Proprietà chimiche

• Peso molecolare: 141.21
• Formula: C₈H₁₅NO
• Colore/Forma: Colourless oil
• InChI: InChI=1S/C8H15NO/c1-2-4-9(5-3-1)6-8-7-10-8/h8H,1-7H2
• InChI key: InChIKey=JWYRPOYJRRHHIL-UHFFFAOYSA-N
• SMILES: C1CCN(CC2CO2)CC1