4-Hydroxy Estradiol 1-N3-Adenine

CAS: 428506-88-1

Rif. TR-H942100

Informazioni sul prodotto

• Nome: 4-Hydroxy Estradiol 1-N3-Adenine
• Sinonimi: (17ß)-1-(6-Amino-3H-purin-3-yl)estra-1,3,5(10)-triene-3,4,17-triol, 4-OH-E2-1-N3Ade

Descrizione

Applications 4-Hydroxy Estradiol 1-N3-Adenine is an estrogen metabolite formed with DNA which can lead to the mutations that initiate breast, prostate, and other types of cancer. The N3Ade depurinating adducts could serve as biomarkers to predict the risk of breast cancer.
References Chakravarti, D., et al.: Mutat. Res., 456, 17 (2000), Liehr, J., et al.: Endocr. Rev., 21, 4054 (2000), Chakravarti, D., et al.: Oncogene, 20, 7945 (2001), Cavalieri, E., et al.: Chem. Res. Toxicol., 14, 1041 (2002),

• Marchio: TRC

Proprietà chimiche

• Peso molecolare: 421.49
• Formula: C₂₃H₂₇N₅O₃
• Colore/Forma: Neat
• InChI: InChI=1S/C23H27N5O3/c1-23-7-6-12-11(14(23)4-5-17(23)30)2-3-13-18(12)15(8-16(29)20(13)31)28-10-27-21(24)19-22(28)26-9-25-19/h8-12,14,17,29-31H,2-7,24H2,1H3/t11-,12+,14+,17+,23+/m1/s1
• InChI key: InChIKey=LWOXXVDIEGNZNP-GXPADDFNSA-N
• SMILES: C[C@]12CC[C@@H]3c4c(-n5cnc(N)c6ncnc5-6)cc(O)c(O)c4CC[C@H]3[C@@H]1CC[C@@H]2O